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The interplay between effector binding and allostery in an engineered protein switch

The protein design rules for engineering allosteric regulation are not well understood. A fundamental understanding of the determinants of ligand binding in an allosteric context could facilitate the design and construction of versatile protein switches and biosensors. Here, we conducted extensive i...

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Publicat a:Protein Sci
Autors principals: Choi, Jay H., Xiong, Tina, Ostermeier, Marc
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338240/
https://ncbi.nlm.nih.gov/pubmed/27272021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2962
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