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Structural basis for agonism and antagonism of hepatocyte growth factor

Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. HGF has t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tolbert, W. David, Daugherty-Holtrop, Jennifer, Gherardi, Ermanno, Vande Woude, George, Xu, H. Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922134/
https://ncbi.nlm.nih.gov/pubmed/20624990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005183107
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