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Structural basis for agonism and antagonism of hepatocyte growth factor
Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. HGF has t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922134/ https://ncbi.nlm.nih.gov/pubmed/20624990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005183107 |
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