Wordt geladen...
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Hepatocyte growth factor (HGF) activates the Met receptor tyrosine kinase by binding and promoting receptor dimerization. Here we describe a mechanistic basis for designing Met antagonists based on NK1, a natural variant of HGF containing the N-terminal and the first kringle domain. Through detailed...
Bewaard in:
| Hoofdauteurs: | , , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2007
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1965485/ https://ncbi.nlm.nih.gov/pubmed/17804794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704290104 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|