Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

Understanding the factors that contribute to age-related cognitive decline is imperative, particularly as age is the major risk factor for several neurodegenerative disorders. Levels of several cytokines increase in the brain during aging, including IL-1β, whose levels positively correlate with cogn...

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Hauptverfasser: Majumder, Smita, Caccamo, Antonella, Medina, David X., Benavides, Adriana D., Javors, Martin A., Kraig, Ellen, Strong, Randy, Richardson, Arlan, Oddo, Salvatore
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306461/
https://ncbi.nlm.nih.gov/pubmed/22212527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00791.x
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