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Combined MEK and VEGFR Inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis

PURPOSE: Ras/Raf/MEK/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a potent, selective, and orally available MEK1/2 inhibitor. In the current study, we evaluated the therapeutic efficacy of selumetinib alone or with cediranib, an orally available potent inhibito...

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Autori principali: Takahashi, Osamu, Komaki, Ritsuko, Smith, Paul D., Jürgensmeier, Juliane M., Ryan, Anderson, Bekele, B. Nebiyou, Wistuba, Ignacio I., Jacoby, Jörg J., Korshunova, Maria V., Biernacka, Anna, Erez, Baruch, Hosho, Keiko, Herbst, Roy S., O’Reilly, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306446/
https://ncbi.nlm.nih.gov/pubmed/22275507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2324
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