Combined MEK and VEGFR Inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis

PURPOSE: Ras/Raf/MEK/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a potent, selective, and orally available MEK1/2 inhibitor. In the current study, we evaluated the therapeutic efficacy of selumetinib alone or with cediranib, an orally available potent inhibito...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Takahashi, Osamu, Komaki, Ritsuko, Smith, Paul D., Jürgensmeier, Juliane M., Ryan, Anderson, Bekele, B. Nebiyou, Wistuba, Ignacio I., Jacoby, Jörg J., Korshunova, Maria V., Biernacka, Anna, Erez, Baruch, Hosho, Keiko, Herbst, Roy S., O’Reilly, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306446/
https://ncbi.nlm.nih.gov/pubmed/22275507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2324
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge