Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small cell lung cancer

PURPOSE: Conventional therapies for lung cancer have reached a therapeutic plateau. We therefore evaluated the feasibility of combined VEGFR2 and EGFR targeting with radiation therapy in an orthotopic model that closely recapitulates the clinical presentation of human lung cancer. METHODS AND MATERI...

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Détails bibliographiques
Auteurs principaux: Shibuya, Keiko, Komaki, Ritsuko, Shintani, Tomoaki, Itasaka, Satoshi, Ryan, Anderson, Jürgensmeier, Juliane M., Milas, Luka, Ang, Kian, Herbst, Roy S., O'Reilly, Michael S.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151850/
https://ncbi.nlm.nih.gov/pubmed/17889445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2007.07.2350
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