Treatment with HIF-1α Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice

INTRODUCTION: PX-478 is a potent small-molecule inhibitor of HIF-1α. In preclinical studies, it had antitumor activity against various solid tumors in subcutaneous xenografts but had no measurable activity against a non-small cell lung cancer (NSCLC) xenograft. To determine the effectiveness of PX-4...

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Main Authors: Jacoby, Jörg J., Erez, Baruch, Korshunova, Maria V., Williams, Ryan R., Furutani, Kazuhisa, Takahashi, Osamu, Kirkpatrick, Lynn, Lippman, Scott M., Powis, Garth, O’Reilly, Michael S., Herbst, Roy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782111/
https://ncbi.nlm.nih.gov/pubmed/20512076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3181dc211f
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