Dynamic Contrast-Enhanced and Diffusion MRI Show Rapid and Dramatic Changes in Tumor Microenvironment in Response to Inhibition of HIF-1α Using PX-478

PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1α, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanc...

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Detalhes bibliográficos
Main Authors: Jordan, Bénédicte F, Runquist, Matthew, Raghunand, Natarajan, Baker, Amanda, Williams, Ryan, Kirkpatrick, Lynn, Powis, Garth, Gillies, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501160/
https://ncbi.nlm.nih.gov/pubmed/15967100
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