The 3′ Untranslated Regions of Influenza Genomic Sequences Are 5′PPP-Independent Ligands for RIG-I

Retinoic acid inducible gene-I (RIG-I) is a key regulator of antiviral immunity. RIG-I is generally thought to be activated by ssRNA species containing a 5′-triphosphate (PPP) group or by unphosphorylated dsRNA up to ∼300 bp in length. However, it is not yet clear how changes in the length, nucleoti...

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Bibliografische gegevens
Hoofdauteurs: Davis, William G., Bowzard, J. Bradford, Sharma, Suresh D., Wiens, Mayim E., Ranjan, Priya, Gangappa, Shivaprakash, Stuchlik, Olga, Pohl, Jan, Donis, Ruben O., Katz, Jacqueline M., Cameron, Craig E., Fujita, Takashi, Sambhara, Suryaprakash
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305289/
https://ncbi.nlm.nih.gov/pubmed/22438882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032661
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