A Dual-Functioning 5ʹ-PPP-NS1shRNA that Activates a RIG-I Antiviral Pathway and Suppresses Influenza NS1

Retinoic acid-inducible gene-I (RIG-I) is a cytosolic pathogen sensor that is crucial against a number of viral infections. Many viruses have evolved to inhibit pathogen sensors to suppress host innate immune responses. In the case of influenza, nonstructural protein 1 (NS1) suppresses RIG-I functio...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Singh, Neetu, Ranjan, Priya, Cao, Weiping, Patel, Jenish, Gangappa, Shivaprakash, Davidson, Bruce A., Sullivan, John M., Prasad, Paras N., Knight, Paul R., Sambhara, Suryaprakash
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049568/
https://ncbi.nlm.nih.gov/pubmed/32160710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.01.025
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