5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

BACKGROUND: Emergence of drug-resistant strains of influenza viruses, including avian H5N1 with pandemic potential, 1918 and 2009 A/H1N1 pandemic viruses to currently used antiviral agents, neuraminidase inhibitors and M2 Ion channel blockers, underscores the importance of developing novel antiviral...

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Bibliografiske detaljer
Main Authors: Ranjan, Priya, Jayashankar, Lakshmi, Deyde, Varough, Zeng, Hui, Davis, William G, Pearce, Melissa B, Bowzard, John B, Hoelscher, Mary A, Jeisy-Scott, Victoria, Wiens, Mayim E, Gangappa, Shivaprakash, Gubareva, Larisa, García-Sastre, Adolfo, Katz, Jacqueline M, Tumpey, Terrence M, Fujita, Takashi, Sambhara, Suryaprakash
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891689/
https://ncbi.nlm.nih.gov/pubmed/20492658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-102
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