The 3′ Untranslated Regions of Influenza Genomic Sequences Are 5′PPP-Independent Ligands for RIG-I

Retinoic acid inducible gene-I (RIG-I) is a key regulator of antiviral immunity. RIG-I is generally thought to be activated by ssRNA species containing a 5′-triphosphate (PPP) group or by unphosphorylated dsRNA up to ∼300 bp in length. However, it is not yet clear how changes in the length, nucleoti...

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Autors principals: Davis, William G., Bowzard, J. Bradford, Sharma, Suresh D., Wiens, Mayim E., Ranjan, Priya, Gangappa, Shivaprakash, Stuchlik, Olga, Pohl, Jan, Donis, Ruben O., Katz, Jacqueline M., Cameron, Craig E., Fujita, Takashi, Sambhara, Suryaprakash
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305289/
https://ncbi.nlm.nih.gov/pubmed/22438882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032661
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