Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines

BACKGROUND/AIMS: Hypoxia-inducible factor-1α (HIF-1α) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of the extracellular matrix in hypoxia. This study evalua...

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Autors principals: Choi, Sung Hoon, Shin, Hye Won, Park, Jun Yong, Yoo, Ji Young, Kim, Do Young, Ro, Weon Sang, Yun, Chae-Ok, Han, Kwang-Hyub
Format: Artigo
Idioma:Inglês
Publicat: The Korean Association for the Study of the Liver 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304594/
https://ncbi.nlm.nih.gov/pubmed/20924210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3350/kjhep.2010.16.3.280
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