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Fetal Hemoglobin in Sickle Cell Anemia: Molecular Characterization of the Unusually High Fetal Hemoglobin Phenotype in African Americans
Fetal hemoglobin (HbF) is a major modifier of disease severity in sickle cell anemia (SCA). Three major HbF quantitative trait loci (QTL) are known: the Xmn I site upstream of (G)γ-globin gene (HBG2) on chromosome 11p15, BCL11A on chromosome 2p16, and HBS1L-MYB intergenic polymorphism (HMIP) on chro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302931/ https://ncbi.nlm.nih.gov/pubmed/22139998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.22221 |
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