The Genetics of Hemoglobin A(2) Regulation in Sickle Cell Anemia

Hemoglobin A(2), a tetramer of α- and δ-globin chains, comprises less than 3% of total hemoglobin in normal adults. In northern Europeans, single nucleotide polymorphisms (SNPs) in the HBS1L-MYB locus on chromosome 6q and the HBB cluster on chromosome 11p were associated with HbA(2) levels. We exami...

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Gepubliceerd in:Am J Hematol
Hoofdauteurs: Griffin, Paula J., Sebastiani, Paola, Edward, Heather, Baldwin, Clinton T., Gladwin, Mark, Gordeuk, Victor, Chui, David H.K., Steinberg, Martin H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298130/
https://ncbi.nlm.nih.gov/pubmed/25042611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23811
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