Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of HIV-1 integrase to irreversibly link the reverse-transcribed viral DNA to the host genome. INSTIs have proven their high efficiency in inhibiting viral replication in vitro and in patients. However, firs...

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Autores principales: Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Oliveira, Maureen, Singhroy, Diane N., Fujiwara, Tamio, Underwood, Mark R., Wainberg, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302270/
https://ncbi.nlm.nih.gov/pubmed/22205735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06591-11
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