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Thymic negative selection is functional in NOD mice

Based on analyses of multiple TCR transgenic (tg) models, the emergence of pathogenic T cells in diabetes-prone NOD mice has been ascribed to a failure to censure autoreactive clones in the thymus. In contrast, using isolated and preselected thymocytes, we show that nonobese diabetic (NOD) genetic v...

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Detalhes bibliográficos
Main Authors: Mingueneau, Michael, Jiang, Wenyu, Feuerer, Markus, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302233/
https://ncbi.nlm.nih.gov/pubmed/22329992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112593
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