Enhanced thymic selection of FoxP3(+) regulatory T cells in the NOD mouse model of autoimmune diabetes

FoxP3(+)CD4(+) regulatory T cells (Tregs) play a key role in the maintenance of peripheral self-tolerance, and it has been suggested that diabetes-susceptible nonobese diabetic (NOD) mice are defective in the generation and numbers of Tregs. We found thymic selection of Tregs to be under genetic con...

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Detalhes bibliográficos
Main Authors: Feuerer, Markus, Jiang, Wenyu, Holler, Phillip D., Satpathy, Ansuman, Campbell, Christopher, Bogue, Molly, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084317/
https://ncbi.nlm.nih.gov/pubmed/17991775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708899104
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