The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

FoxP3(+) regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes (T1D) in particular, prompting the hypothesis that a deficiency in Tregs is a critical determinant of diabetes susceptibility in NOD mice. However, tests of this hypothesis have yielded contradictory results. We confir...

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Bibliografiske detaljer
Main Authors: D'Alise, Anna Morena, Auyeung, Vincent, Feuerer, Markus, Nishio, Junko, Fontenot, Jason, Benoist, Christophe, Mathis, Diane
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604930/
https://ncbi.nlm.nih.gov/pubmed/19073938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810713105
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