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Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
Immature thymocytes expressing autoreactive T-cell receptors (TCR) can adopt differing cell fates: clonal deletion by apoptosis or deviation into alternative lineages such as FoxP3(+) regulatory T cells (Treg). We revisited the role of the transcription factor Nr4a1 (Nur77), an immediate-early respo...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309794/ https://ncbi.nlm.nih.gov/pubmed/22345564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200090109 |
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