A role for insulator elements in the regulation of gene expression response to hypoxia

Hypoxia inducible factor (HIF) up-regulates the transcription of a few hundred genes required for the adaptation to hypoxia. This restricted set of targets is in sharp contrast with the widespread distribution of the HIF binding motif throughout the genome. Here, we investigated the transcriptional...

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Bibliographic Details
Main Authors: Tiana, Maria, Villar, Diego, Pérez-Guijarro, Eva, Gómez-Maldonado, Laura, Moltó, Eduardo, Fernández-Miñán, Ana, Gómez-Skarmeta, Jose Luis, Montoliu, Lluís, del Peso, Luis
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3300008/
https://ncbi.nlm.nih.gov/pubmed/22067454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr842
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