Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR–Cas9-mediated mutagenesis

Newly developed genome-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)–Cas9 system, allow simple and rapid genetic modification in most model organisms and human cell lines. Here, we report the production and analysis of mice carrying the inactivation via...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Seruggia, Davide, Fernández, Almudena, Cantero, Marta, Pelczar, Pawel, Montoliu, Lluis
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446435/
https://ncbi.nlm.nih.gov/pubmed/25897126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv375
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