Repurposing the CRISPR-Cas9 system for targeted DNA methylation

Epigenetic studies relied so far on correlations between epigenetic marks and gene expression pattern. Technologies developed for epigenome editing now enable direct study of functional relevance of precise epigenetic modifications and gene regulation. The reversible nature of epigenetic modificatio...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Vojta, Aleksandar, Dobrinić, Paula, Tadić, Vanja, Bočkor, Luka, Korać, Petra, Julg, Boris, Klasić, Marija, Zoldoš, Vlatka
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937303/
https://ncbi.nlm.nih.gov/pubmed/26969735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw159
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