Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system

Establishing causal relationship between epigenetic marks and gene transcription requires molecular tools, which can precisely modify specific genomic regions. Here, we present a modular and extensible CRISPR/dCas9-based toolbox for epigenetic editing and direct gene regulation. It features a system...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Josipović, Goran, Tadić, Vanja, Klasić, Marija, Zanki, Vladimir, Bečeheli, Ivona, Chung, Felicia, Ghantous, Akram, Keser, Toma, Madunić, Josip, Bošković, Maria, Lauc, Gordan, Herceg, Zdenko, Vojta, Aleksandar, Zoldoš, Vlatka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765142/
https://ncbi.nlm.nih.gov/pubmed/31410472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz709
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