The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras

The connection between cancer and inflammation is widely recognized; yet the underlying molecular mechanisms are poorly understood. We report here that TIPE2 provides a molecular bridge from inflammation to cancer by targeting the Ras signaling pathway. TIPE2 binds the Ras-interacting domain of the...

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Библиографические подробности
Главные авторы: Gus-Brautbar, Yael, Johnson, Derek, Zhang, Li, Sun, Honghong, Wang, Peng, Zhang, Shirley, Zhang, Lining, Chen, Youhai H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299909/
https://ncbi.nlm.nih.gov/pubmed/22326055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.01.006
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