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The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain
The deposition of the β-amyloid (Aβ) peptide in senile plaques and cerebral Aβ-amyloid angiopathy can be seeded in β-amyloid precursor protein (APP)-transgenic mice by the intracerebral infusion of brain extracts containing aggregated Aβ. Previous studies of seeded β-amyloid induction have used rela...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3297471/ https://ncbi.nlm.nih.gov/pubmed/22101366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0912-1 |
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