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The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

The deposition of the β-amyloid (Aβ) peptide in senile plaques and cerebral Aβ-amyloid angiopathy can be seeded in β-amyloid precursor protein (APP)-transgenic mice by the intracerebral infusion of brain extracts containing aggregated Aβ. Previous studies of seeded β-amyloid induction have used rela...

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Main Authors: Hamaguchi, Tsuyoshi, Eisele, Yvonne S., Varvel, Nicholas H., Lamb, Bruce T., Walker, Lary C., Jucker, Mathias
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297471/
https://ncbi.nlm.nih.gov/pubmed/22101366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0912-1
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