E22Q-Mutant Aβ Peptide (AβDutch) Increases Vascular but Reduces Parenchymal Aβ Deposition

Patients that have hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) generate both wild-type β-amyloid (Aβwt) and E22Q-mutant β-amyloid (AβDutch). Postmortem analysis of HCHWA-D brains reveals severe cerebral amyloid angiopathy with very little parenchymal amyloid deposition. To i...

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Detalhes bibliográficos
Main Authors: Herzig, Martin C., Eisele, Yvonne S., Staufenbiel, Matthias, Jucker, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665734/
https://ncbi.nlm.nih.gov/pubmed/19218342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080790
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