Serine Hydroxymethyltransferase 1 and 2: Gene Sequence Variation and Functional Genomic Characterization

Serine hydroxymethyltransferase (SHMT) catalyzes the transfer of a beta carbon from serine to tetrahydrofolate (THF) to form glycine and 5,10-methylene-THF. This reaction plays an important role in neurotransmitter synthesis and metabolism. We set out to resequence SHMT1 and SHMT2, followed by funct...

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Autors principals: Hebbring, Scott J., Chai, Yubo, Ji, Yuan, Abo, Ryan P., Jenkins, Gregory D., Fridley, Brooke, Zhang, Jianping, Eckloff, Bruce W., Wieben, Eric D., Weinshilboum, Richard M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296836/
https://ncbi.nlm.nih.gov/pubmed/22220685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07646.x
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