A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are lac...

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Autors principals: Bach, Anders, Clausen, Bettina H., Møller, Magda, Vestergaard, Bente, Chi, Celestine N., Round, Adam, Sørensen, Pernille L., Nissen, Klaus B., Kastrup, Jette S., Gajhede, Michael, Jemth, Per, Kristensen, Anders S., Lundström, Patrik, Lambertsen, Kate L., Strømgaard, Kristian
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295328/
https://ncbi.nlm.nih.gov/pubmed/22343531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113761109
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