A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are lac...

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Detalhes bibliográficos
Main Authors: Bach, Anders, Clausen, Bettina H., Møller, Magda, Vestergaard, Bente, Chi, Celestine N., Round, Adam, Sørensen, Pernille L., Nissen, Klaus B., Kastrup, Jette S., Gajhede, Michael, Jemth, Per, Kristensen, Anders S., Lundström, Patrik, Lambertsen, Kate L., Strømgaard, Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295328/
https://ncbi.nlm.nih.gov/pubmed/22343531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113761109
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