A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are lac...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Bach, Anders, Clausen, Bettina H., Møller, Magda, Vestergaard, Bente, Chi, Celestine N., Round, Adam, Sørensen, Pernille L., Nissen, Klaus B., Kastrup, Jette S., Gajhede, Michael, Jemth, Per, Kristensen, Anders S., Lundström, Patrik, Lambertsen, Kate L., Strømgaard, Kristian
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295328/
https://ncbi.nlm.nih.gov/pubmed/22343531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113761109
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