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TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
Although aberrant microRNA (miRNA) expression is linked to human diseases including cancer, the mechanisms that regulate the expression of each individual miRNA remain largely unknown. TAR DNA-binding protein-43 (TDP-43) is homologous to the heterogeneous nuclear ribonucleoproteins (hnRNPs), which a...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3295278/ https://ncbi.nlm.nih.gov/pubmed/22323604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112427109 |
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