Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome sequencing of 44 Wilms tumours, identifying missense mutations in the microRNA (miRNA)-processing enzymes DROSHA and DICER1, and novel mutations in MYCN, SMARCA4 and ARID1A. Examination of tumour miRNA expression...

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Autors principals: Rakheja, Dinesh, Chen, Kenneth S., Liu, Yangjian, Shukla, Abhay A., Schmid, Vanessa, Chang, Tsung-Cheng, Khokhar, Shama, Wickiser, Jonathan E., Karandikar, Nitin J., Malter, James S., Mendell, Joshua T., Amatruda, James F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159681/
https://ncbi.nlm.nih.gov/pubmed/25190313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5802
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