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DNA Repair Functions That Control Sensitivity to Topoisomerase-Targeting Drugs
DNA topoisomerases play critical roles in a wide range of cellular processes by altering DNA topology to facilitate replication, transcription, and chromosome segregation. Topoisomerases alter DNA topology by introducing transient DNA strand breaks that involve a covalent protein DNA intermediate. M...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC329506/ https://ncbi.nlm.nih.gov/pubmed/14871939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.3.1.82-90.2004 |
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