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Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness

Recent studies link early rhinovirus (RV) infections to later asthma development. We hypothesized that neonatal RV infection leads to an IL-13-driven asthma-like phenotype in mice. BALB/c mice were inoculated with RV1B or sham on day 7 of life. Viral RNA persisted in the neonatal lung up to 7 days a...

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書誌詳細
主要な著者: Schneider, Dina, Hong, Jun Y., Popova, Antonia P., Bowman, Emily R., Linn, Marisa J., McLean, Alan M., Zhao, Ying, Sonstein, Joanne, Bentley, J. Kelley, Weinberg, Jason B., Lukacs, Nicholas W., Curtis, Jeffrey L., Sajjan, Uma S., Hershenson, Marc B.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294163/
https://ncbi.nlm.nih.gov/pubmed/22331068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101391
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