Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness

Recent studies link early rhinovirus (RV) infections to later asthma development. We hypothesized that neonatal RV infection leads to an IL-13-driven asthma-like phenotype in mice. BALB/c mice were inoculated with RV1B or sham on day 7 of life. Viral RNA persisted in the neonatal lung up to 7 days a...

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Autors principals: Schneider, Dina, Hong, Jun Y., Popova, Antonia P., Bowman, Emily R., Linn, Marisa J., McLean, Alan M., Zhao, Ying, Sonstein, Joanne, Bentley, J. Kelley, Weinberg, Jason B., Lukacs, Nicholas W., Curtis, Jeffrey L., Sajjan, Uma S., Hershenson, Marc B.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294163/
https://ncbi.nlm.nih.gov/pubmed/22331068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101391
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