MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

Rhinovirus (RV), a single-stranded RNA picornavirus, is the most frequent cause of asthma exacerbations. We previously demonstrated in human bronchial epithelial cells that melanoma differentiation-associated gene (MDA)-5 and the adaptor protein for Toll-like receptor (TLR)-3 are each required for m...

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Detalhes bibliográficos
Main Authors: Wang, Qiong, Miller, David J., Bowman, Emily R., Nagarkar, Deepti R., Schneider, Dina, Zhao, Ying, Linn, Marisa J., Goldsmith, Adam M., Bentley, J. Kelley, Sajjan, Umadevi S., Hershenson, Marc B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102730/
https://ncbi.nlm.nih.gov/pubmed/21637773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002070
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