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Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness

Recent studies link early rhinovirus (RV) infections to later asthma development. We hypothesized that neonatal RV infection leads to an IL-13-driven asthma-like phenotype in mice. BALB/c mice were inoculated with RV1B or sham on day 7 of life. Viral RNA persisted in the neonatal lung up to 7 days a...

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Main Authors:	Schneider, Dina, Hong, Jun Y., Popova, Antonia P., Bowman, Emily R., Linn, Marisa J., McLean, Alan M., Zhao, Ying, Sonstein, Joanne, Bentley, J. Kelley, Weinberg, Jason B., Lukacs, Nicholas W., Curtis, Jeffrey L., Sajjan, Uma S., Hershenson, Marc B.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2012
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3294163/ https://ncbi.nlm.nih.gov/pubmed/22331068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101391
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Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness

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