Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness

Recent studies link early rhinovirus (RV) infections to later asthma development. We hypothesized that neonatal RV infection leads to an IL-13-driven asthma-like phenotype in mice. BALB/c mice were inoculated with RV1B or sham on day 7 of life. Viral RNA persisted in the neonatal lung up to 7 days a...

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Autores principales: Schneider, Dina, Hong, Jun Y., Popova, Antonia P., Bowman, Emily R., Linn, Marisa J., McLean, Alan M., Zhao, Ying, Sonstein, Joanne, Bentley, J. Kelley, Weinberg, Jason B., Lukacs, Nicholas W., Curtis, Jeffrey L., Sajjan, Uma S., Hershenson, Marc B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294163/
https://ncbi.nlm.nih.gov/pubmed/22331068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101391
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