A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation

The activation of heterodimeric integrin adhesion receptors from low to high affinity states occurs in response to intracellular signals that act on the short cytoplasmic tails of integrin β subunits. Binding of the talin FERM (four-point-one, ezrin, radixin, moesin) domain to the integrin β tail pr...

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Main Authors: Bouaouina, Mohamed, Goult, Benjamin T., Huet-Calderwood, Clotilde, Bate, Neil, Brahme, Nina N., Barsukov, Igor L., Critchley, David R., Calderwood, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293583/
https://ncbi.nlm.nih.gov/pubmed/22235127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.330845
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