PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)

One of the main characteristics of the transmissible isoform of the prion protein (PrP(Sc)) is its partial resistance to proteinase K (PK) digestion. Diagnosis of prion disease typically relies upon immunodetection of PK-digested PrP(Sc) following Western blot or ELISA. More recently, researchers de...

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Autores principales: Sajnani, Gustavo, Silva, Christopher J., Ramos, Adriana, Pastrana, Miguel A., Onisko, Bruce C., Erickson, Melissa L., Antaki, Elizabeth M., Dynin, Irina, Vázquez-Fernández, Ester, Sigurdson, Christina J., Carter, J. Mark, Requena, Jesús R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291653/
https://ncbi.nlm.nih.gov/pubmed/22396643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002547
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