Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis

Very solid evidence suggests that the core of full length PrP(Sc) is a 4-rung β-solenoid, and that individual PrP(Sc) subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrP(Sc) solenoid. Using high resolution SDS-PAG...

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Vydáno v:PLoS Pathog
Hlavní autoři: Sevillano, Alejandro M., Fernández-Borges, Natalia, Younas, Neelam, Wang, Fei, R. Elezgarai, Saioa, Bravo, Susana, Vázquez-Fernández, Ester, Rosa, Isaac, Eraña, Hasier, Gil, David, Veiga, Sonia, Vidal, Enric, Erickson-Beltran, Melissa L., Guitián, Esteban, Silva, Christopher J., Nonno, Romolo, Ma, Jiyan, Castilla, Joaquín, R. Requena, Jesús
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809102/
https://ncbi.nlm.nih.gov/pubmed/29385212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006797
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