Ultra-Efficient PrP(Sc) Amplification Highlights Potentialities and Pitfalls of PMCA Technology

In order to investigate the potential of voles to reproduce in vitro the efficiency of prion replication previously observed in vivo, we seeded protein misfolding cyclic amplification (PMCA) reactions with either rodent-adapted Transmissible Spongiform Encephalopathy (TSE) strains or natural TSE iso...

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Bibliografiske detaljer
Main Authors: Cosseddu, Gian Mario, Nonno, Romolo, Vaccari, Gabriele, Bucalossi, Cecilia, Fernandez-Borges, Natalia, Di Bari, Michele Angelo, Castilla, Joaquin, Agrimi, Umberto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219717/
https://ncbi.nlm.nih.gov/pubmed/22114554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002370
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