A New Method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease-Resistant PrP(Sc)

Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrP(Sc), a disease-associated isoform of the host-encoded cellular protein (PrP(C)). Molecular strain typing approa...

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Detalhes bibliográficos
Main Authors: Pirisinu, Laura, Di Bari, Michele, Marcon, Stefano, Vaccari, Gabriele, D'Agostino, Claudia, Fazzi, Paola, Esposito, Elena, Galeno, Roberta, Langeveld, Jan, Agrimi, Umberto, Nonno, Romolo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939050/
https://ncbi.nlm.nih.gov/pubmed/20856860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012723
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