Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis

Very solid evidence suggests that the core of full length PrP(Sc) is a 4-rung β-solenoid, and that individual PrP(Sc) subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrP(Sc) solenoid. Using high resolution SDS-PAG...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:PLoS Pathog
Glavni autori: Sevillano, Alejandro M., Fernández-Borges, Natalia, Younas, Neelam, Wang, Fei, R. Elezgarai, Saioa, Bravo, Susana, Vázquez-Fernández, Ester, Rosa, Isaac, Eraña, Hasier, Gil, David, Veiga, Sonia, Vidal, Enric, Erickson-Beltran, Melissa L., Guitián, Esteban, Silva, Christopher J., Nonno, Romolo, Ma, Jiyan, Castilla, Joaquín, R. Requena, Jesús
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809102/
https://ncbi.nlm.nih.gov/pubmed/29385212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006797
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items