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Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrP(Sc)
While elucidating the peculiar epitope of the α-PrP mAb IPC2, we found that PrP(Sc) exhibits the sulfoxidation of residue M213 as a covalent signature. Subsequent computational analysis predicted that the presence of sulfoxide groups at both Met residues 206 and 213 destabilize the α-fold, suggestin...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895666/ https://ncbi.nlm.nih.gov/pubmed/20625387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000977 |
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