PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

Defective Fas signaling leads to resistance to various anticancer therapies. Presence of potential inhibitors of Fas which could block Fas signaling can explain cancer cells resistance to apoptosis. We identified promyelocytic leukemia protein (PML) as a Fas-interacting protein using mass spectromet...

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Hauptverfasser: Tao, Rong-Hua, Berkova, Zuzana, Wise, Jillian F., Rezaeian, Abdol-Hossein, Daniluk, Urszula, Ao, Xue, Hawke, David H., Karp, Judith E., Lin, Hui-Kuan, Molldrem, Jeffrey J., Samaniego, Felipe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291494/
https://ncbi.nlm.nih.gov/pubmed/21803845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-349670
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