PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

Defective Fas signaling leads to resistance to various anticancer therapies. Presence of potential inhibitors of Fas which could block Fas signaling can explain cancer cells resistance to apoptosis. We identified promyelocytic leukemia protein (PML) as a Fas-interacting protein using mass spectromet...

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Autors principals: Tao, Rong-Hua, Berkova, Zuzana, Wise, Jillian F., Rezaeian, Abdol-Hossein, Daniluk, Urszula, Ao, Xue, Hawke, David H., Karp, Judith E., Lin, Hui-Kuan, Molldrem, Jeffrey J., Samaniego, Felipe
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291494/
https://ncbi.nlm.nih.gov/pubmed/21803845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-349670
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