Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane

Natural Killer (NK) cells and Cytotoxic T lymphocytes (CTL) are critical for the immune response against virus infections or transformed cells. They kill target cells via polarized exocytosis of lytic proteins from secretory lysosomes (SL). Rab27a and munc13-4 interact directly and are required for...

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Auteurs principaux: Elstak, Edo D., Neeft, Maaike, Nehme, Nadine T., Callebaut, Isabelle, de Saint Basile, Geneviève, van der Sluijs, Peter
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
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Article Addendum
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291317/
https://ncbi.nlm.nih.gov/pubmed/22482013
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