Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

The GTPase Rab27A interacts with myosin-VIIa and myosin-Va via MyRIP or melanophilin and mediates melanosome binding to actin. Here we show that Rab27A and MyRIP are associated with secretory granules (SGs) in adrenal chromaffin cells and PC12 cells. Overexpression of Rab27A, GTPase-deficient Rab27A...

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Xehetasun bibliografikoak
Egile Nagusiak: Desnos, Claire, Schonn, Jean-Sébastien, Huet, Sébastien, Tran, Viet Samuel, El-Amraoui, Aziz, Raposo, Graça, Fanget, Isabelle, Chapuis, Catherine, Ménasché, Gaël, de Saint Basile, Geneviève, Petit, Christine, Cribier, Sophie, Henry, Jean-Pierre, Darchen, François
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2003
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173641/
https://ncbi.nlm.nih.gov/pubmed/14610058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302157
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