Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane

Natural Killer (NK) cells and Cytotoxic T lymphocytes (CTL) are critical for the immune response against virus infections or transformed cells. They kill target cells via polarized exocytosis of lytic proteins from secretory lysosomes (SL). Rab27a and munc13-4 interact directly and are required for...

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Detalhes bibliográficos
Main Authors: Elstak, Edo D., Neeft, Maaike, Nehme, Nadine T., Callebaut, Isabelle, de Saint Basile, Geneviève, van der Sluijs, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Article Addendum
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291317/
https://ncbi.nlm.nih.gov/pubmed/22482013
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